Aspirin cures erythromelalgia and cerebrovascular disturbances in JAK2-thrombocythemia through platelet-cycloxygenase inhibition

Figure 10 Thrombotic occlusion of arterioles on top of fibrouscular intimal proliferation. Thromboangiitis oblitterans (left panel) and recanalisation of arterioles showing vessel wall fibosis of arterioles in two cases of erythromelalgia complicated by acrocyanosis and digital gangrene (middle panel). Source Michiels 1981. Oniony structure by vascular and perivascular fibrosis of occluded fibromusclar intimal proliferation in acrocyanotic digital ischemia of untreated endstage erythromelalgia that had transformed into aspirin resistent Raynaud phenomenon (right). Source Michiels 1981.