Aspirin cures erythromelalgia and cerebrovascular disturbances in JAK2-thrombocythemia through platelet-cycloxygenase inhibition

Figure 9 Arterioles with swelling of endothelial cells, proliferation of cells of the inner layer below the media and normal venules, capillaries and nerves (upper and left), and elastica von Gieson stain showing a normal membrana elestica interna (mei) in a normal arteriole (A). Source Michiels 1981. The membrana elstica interna (mei) is splitted up and fragmented between the proliferating cells in arteriole B with intimal proliferation in in skin areas of very typical red congested erythromelalgia within one week after discontinuation of aspirin in two cases with essential thrombocythemia. Source Michiels 1981. Immunofluorescence of proliferating cells in the intima of affected arterioles shows on layer endothelial cells with antiserum against factor VIII and multilayer proliferation of smooth muscle cells with antiserum against smooth muscle cells indcative for fibromusclar intimal proliferation of affected arterioles in erythromelalgic thrombocythemia (upper). Partial and complete occlusion by a fresh thrombus in acrocyanotic erthomelalgia three weeks after discontinuation of aspirin (lower). Source Michiels 1981.