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World J Hematol. Nov 6, 2014; 3(4): 118-127
Published online Nov 6, 2014. doi: 10.5315/wjh.v3.i4.118
Published online Nov 6, 2014. doi: 10.5315/wjh.v3.i4.118
Figure 3 Inhibitory receptor programmed cell death 1, its ligands and their role in humoral response.
In the absence of an operative programmed cell death 1 (PD-1)/PD-1 Ligand axis, follicular helper T lymphocytes (TFH) increase and autoimmunity may develop (A); memory B cells are formed normally (B); reduced plasma cells (PC) are found (C); Foxp3+ CXCR5+ Bcl-6+ regulatory T cells (TFR) increase and have higher suppressive ability on TFH function leading to impaired antibody responses (D). PD-1: Programmed cell death-1; CXCR5: Chemokine (C-X-C motif) receptor; Bcl: B cell lymphoma.
- Citation: Parodi C, Badano MN, Galassi N, Coraglia A, Baré P, Malbrán A, Bracco MME. Follicular helper T lymphocytes in health and disease. World J Hematol 2014; 3(4): 118-127
- URL: https://www.wjgnet.com/2218-6204/full/v3/i4/118.htm
- DOI: https://dx.doi.org/10.5315/wjh.v3.i4.118