Follicular helper T lymphocytes in health and disease

doi:10.5315/wjh.v3.i4.118

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World Journal of Hematology

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2218-6204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hematol. Nov 6, 2014; 3(4): 118-127
Published online Nov 6, 2014. doi: 10.5315/wjh.v3.i4.118

Table 3 Follicular helper T lymphocytes in autoimmune diseases

Disease	T_FH	Ref.
SLE	Increased CXCR5 and function	[46-48]
Myasthenia gravis	Increased CXCR5 and function	[49]
RA	Increased CXCR5 and function	[1,50]
Juvenile Dermatomyositis	Increased CXCR5 and function Mainly T_FH with Th17 and Th2-like profile	[1]
ATD	Increased CXCR5, IL-21 high	[51]
Multiple Sclerosis	Increased CXCR5 IL-21 and IL-21R in neurons	[52,53]
Sjögren’s syndrome	Increased CXCR5 T_FH with Th17 and Th2-like profile IL-17?	[54,55]

T_FH: Follicular helper T lymphocytes; SLE: Systemic lupus erythematosus; RA: Rheumatoid arthritis; ATD: Autoimmune thyroid disease; CXCR5: Chemokine (C-X-C motif) receptor 5; IL: Interleukin; Th: T helper.

Citation: Parodi C, Badano MN, Galassi N, Coraglia A, Baré P, Malbrán A, Bracco MME. Follicular helper T lymphocytes in health and disease. World J Hematol 2014; 3(4): 118-127
URL: https://www.wjgnet.com/2218-6204/full/v3/i4/118.htm
DOI: https://dx.doi.org/10.5315/wjh.v3.i4.118