Follicular helper T lymphocytes in health and disease

doi:10.5315/wjh.v3.i4.118

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Nov 6, 2014 (publication date) through Feb 6, 2025

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World Journal of Hematology

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2218-6204

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World J Hematol. Nov 6, 2014; 3(4): 118-127
Published online Nov 6, 2014. doi: 10.5315/wjh.v3.i4.118

Table 1 Follicular helper T lymphocytes markers

Marker	Human T_FH		NaïveCD4⁺ T cell	ActivatedNon-T_FH CD4⁺
Marker	T_FH	GC T_FH		ActivatedNon-T_FH CD4⁺
CXCR5	+	++	NaïveCD4⁺ T cell	-	-
Ascl2	?	++	?	?
Bcl-6	+	++	-	-
Blimp-1	-	-	+/-	++/variable
PD-1	+	++	-	Variable
ICOS	+	++	-	Variable
SAP	+	++	+	+
IL-21	+	++	-	Variable
IL-4	-/+	++	-	Th2+
CCR7	-/+	-	++	Variable

T_FH: Follicular helper T lymphocytes; GC: Germinal center; CXCR5: Chemokine (C-X-C motif) receptor 5; Ascl2: Achaete-scute homologue 2; Bcl-6: B cell lymphoma 6; Blimp-1: B lymphocyte-induced maturation protein 1; PD-1: Programmed cell death-1; ICOS: Inducible costimulator; SAP: Signaling adaptor SLAM-associated protein; IL: Interleukin; CCR7: Chemokine (C-C motif) receptor 7; Th: T helper.

Citation: Parodi C, Badano MN, Galassi N, Coraglia A, Baré P, Malbrán A, Bracco MME. Follicular helper T lymphocytes in health and disease. World J Hematol 2014; 3(4): 118-127
URL: https://www.wjgnet.com/2218-6204/full/v3/i4/118.htm
DOI: https://dx.doi.org/10.5315/wjh.v3.i4.118