Age is an independent adverse prognostic factor for overall survival in acute myeloid leukemia in Japan

Table 2 Multivariate analysis of prognostic factors affecting survival in non-acute promyelocytic leukemia patient

Risk factors
Chromosomal abnormality	NCCN	SWOG	CALGB
	HR (95%CI) P	HR (95%CI) P	HR (95%CI) P
Age in years	0.031	0.043	0.026
≤ 64	1	1	1
65-74	1.33 (1.06-1.58)	1.39 (1.13-1.64)	1.40 (1.15-1.66)
≥ 75	1.88 (1.59-2.04)	1.82 (1.60-2.05)	1.91 (1.67-2.13)
Performance status	0.012	0.028	0.019
0-2	1	1	1
3-4	1.94 (1.15-3.26)	1.80 (1.06-3.05)	1.88 (1.11-3.20)
Intensity of induction therapy	0.041	0.029	0.027
Intensive, less-intensive	1	1	1
Best supportive care	1.74 (2.02-2.96)	1.80 (1.06-3.07)	1.83 (1.07-3.14)
Antecedent hematological disease	0.007	0.007	0.004
No	1	1	1
Yes	1.92 (1.20-3.08)	1.90 (1.19-3.05)	2.03 (1.25-3.27)
Chromosomal abnormality	0.001	< 0.001	< 0.001
Favorable, intermediate	1	1	1
Unfavorable	1.98 (1.31-2.99)	1.44 (0.55-3.78)	1.56 (0.63-3.87)

NCCN: National Comprehensive Cancer Network practice guidelines in oncology- v.2.2010; SWOG: Southwest Oncology Group; CALGB: Cancer and Leukemia Group B.