Histone deacetylases, microRNA and leptin crosstalk in pancreatic cancer

Figure 2 Potential crosstalk between leptin signaling, cancer stem cells, histone deacetylases and microRNA. Leptin and its receptor LEPR (OB-R) are involved in the regulation of PCSC markers, Classical HDAC, miR21, and miR200a/b/c. HDAC 1, 2, 3, 8: Histone Deacetylases Class I; HDAC 4, 5, 7, 9: Histone Deacetylases Class IIA; HDAC 6,10: Histone Deacetylases Class IIB; HDAC11: Histone Deacetylase Class IV. MiR200a, miR200b, and miR200c: Tumor Suppressors MicroRNA; MiR21: Oncogenic MicroRNA. CD24, CD44, ALDH1A1, ABCB1, MET, and EPCAM: Pancreatic Cancer Stem Cell Markers. HGF: Hepatocyte growth factor cytokine; LEP: Leptin adipokine; LEPR: Leptin receptor. Data generated from Pathway Studio (Pathway Studio – web; Ariadne Genomics, Inc.). Genes were analyzed by Pathway Studio 11 software (Elsevier, Inc., Atlanta, GA, United States) for disease, cellular processes and miRNA interactions. Only genes that had a P value of 0.05 were reported in this study. Specific references supporting these relationships are shown in Supplemental Table 1. References found by Pathway Studio were exported into an Excel file, column D, that contains the PMID number for the citations.