Estrogen receptor alpha gene amplification in breast cancer: 25 years of debate

Figure 5 Estrogen receptor alpha gene amplification in a breast cancer tumor responding to estradiol treatment. DNA copy number profiles (red) in relation to the genomic position of CCDC170 (blue) and estrogen receptor alpha gene (ESR1) (green) in normal and a breast cancer tumor tissue that harbors amplification of the ESR1 gene. The amplified DNA sequence extends from CCDC170 throughout the promoter region and the coding sequence of ESR1. The mapping of amplification was performed using read counts obtained during whole genome sequencing. Read counts above normal and max reads including ESR1 are indicated in increased darker red shading. Data and graphic illustration according to Li et al[89].