Estrogen receptor alpha gene amplification in breast cancer: 25 years of debate

Figure 3 Estrogen receptor alpha gene single and split signal patterns and their supposed appearance as detected with fluorescence in situ hybridization assays. Green and red spots represent estrogen receptor alpha gene gene probe and centromere 6 probe, respectively. A: Normal disomy with two chromosomes and two gene copies; B: Normal disomy after s-phase with four chromatids and four gene copies; C: Disomy harboring mono allelic gene duplication with two chromosomes and three gene copies[38]. Photos from Moelans et al[40].