Inhibition of N-Myc down regulated gene 1 in in vitro cultured human glioblastoma cells

Figure 1 Hypoxia induced regulation of N-Myc down-regulated gene 1 in human brain cancer hypoxia-inducible factor-1α induced regulation of hypoxia induced N-Myc down-regulated gene 1 expression in human tumour cells. A: Under normoxic oxygenation conditions in the tumor cell microenvironment, hypoxia-inducible factor (HIF)-1α is rapidly degraded via the von Hippel-Lindau tumour suppressor gene product (pVHL)-mediated ubiquitin proteasome pathway; B: When the tumor environment aeration conditions shifts from normoxic to hypoxic aeration conditions, HIF-1α subunit becomes stable, translocates into the cellular nucleus and interacts with co-activators of which its transcription machinery is consisted such as p300/CBP to modulate the transcriptional activity of numerous hypoxia inducible genes, like N-Myc down-regulated gene 1 (NDRG1) in the case and about 61 other hypoxia induced genes[28,40]. HRE: Hypoxia response element.