Mechanisms of acquired resistance of BRCA1/2-driven tumors to platinum compounds and PARP inhibitors

Figure 1 Examples of BRCA1/2 open-reading frame restoration in BRCA1/2-mutated tumors during systemic therapy. A: Secondary 1-bp deletion occurring downstream to the germline mutation (BRCA1 c.5266dupC; described in[22]); B: Secondary 4-bp deletion located upstream to the germline mutation (BRCA1 c.3770_3771delAG; an example from[23]); C: Secondary in-frame deletion/insertion excising the mutation-containing gene fragment (BRCA2 c.5946delT; an example from[24]). ORF: Open-reading frame.