Pharmacotherapy for the management of achalasia: Current status, challenges and future directions

Figure 3 Neuronal sprouting and remodeling of the neuromuscular junction. Remodeling of the neuromuscular junction in extensor digitorum longus muscle at 10 (A-C) and 21 d (D) after a single injection of botulinum neurotoxin type C. Axons and nerve terminals were immunolabelled (red). To localize the junctions, nicotinic acetylcholine receptors were stained (green). Note the sprouts that emerge from the original motor endplate and project along muscle fibers (yellow arrows). Reproduced with permission from Morbiato et al[92].