Evaluation of DNA synthesis with carbon-11-labeled 4′-thiothymidine

Figure 6 Early evaluation of the effectiveness of radiosurgery with 4’-[methyl-¹¹C]-thiothymidine positron emission tomography. A marked decrease in ¹¹C-4DST uptake into metastatic lung cancer was observed 5 d after gamma knife radiosurgery. Although ring form enhancement with cystic formation did not disappear completely, tumor growth was halted by this treatment and the patient has maintained favorable activity of daily living 1 year after treatment. These observations indicated that the effectiveness of gamma knife therapy was correctly monitored by ¹¹C-4DST only 5 d after treatment. Reprinted from Nariai et al[14], with the permission of Springer. ¹¹C-4DST: 4’-[methyl-¹¹C]-thiothymidine; Gd-MRI: Gadolinium-enhanced magnetic resonance image.