Dissection of Z-disc myopalladin gene network involved in the development of restrictive cardiomyopathy using system genetics approach

Table 4 Genes whose gene expression has significant correlation with Mypn and gene product have significant change comparing with KI or KO mice

Protein code	Corr P value	KI/WT	KO/WT	KO/KI
CGNL1	0.0024	1.58	-1.03	-1.63
PKP1	0.0082	1.76	-1.13	-1.99
SYNE11	0.0114	-3.59	5.82	20.82
PYGB	0.0157	1.61	1.16	-1.39
MSN	0.0194	-2.68	4.71	12.57
ANXA3	0.0319	1.23	-1.8	-2.23
MYOM11	0.0335	-1.37	1.58	2.15
ACADS	0.035	-2.01	1.12	2.24
GCC2	0.0375	1.04	-3.78	-3.92
FEZ2	0.0399	1.89	-1.11	-2.12
LATS2	0.0431	-1.58	-1.51	1.04

¹Genes with statistically significant correlation with that of Mypn in mouse hearts. KI: Knock-in Mypn mouse; KO: Knock-out Mypn mouse; WT: Wild type littermates; -: Proteins downregulated compared to WT.