Angiotensin receptor blocker drugs and inhibition of adrenal beta-arrestin-1-dependent aldosterone production: Implications for heart failure therapy

Figure 1 Angiotensin II type 1 receptor and aldosterone production. Schematic representation of the parallel G prt- and βarr1-mediated, AngII-bound AT1R signaling cascades that converge on mitochondrial aldosterone synthesis in adrenocortical zona glomerulosa (AZG) cells. The structure of the proposed AT1R antagonist (2-pentyl-1-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1H-1,3-benzodiazole-7-carboxylic acid)[40], discussed in the text, capable of suppressing both pathways equally well, is also shown (upper left corner). See text for details. G prt: G_q protein; βarr1: β-arrestin1; AngII: Angiotensin II; AT₁R: AngII type 1 receptor.