Physiology of in-situ arterial revascularization in coronary artery bypass grafting: Preoperative, intraoperative and postoperative factors and influences

Figure 1 International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (NCT01471522) trial design. After Stone et al[17]. CCTA may not be performed with estimated glomerular filtration rate < 60 mL/min. Participants in whom CCTA show significant left main disease (≥ 50% stenosis) or no obstructive disease are excluded. CCTA results are otherwise kept blinded. ISCHEMIA: International study of comparative health effectiveness with medical and invasive approaches; CCTA: Coronary computed tomographic angiography; eGFR: Estimated glomerular filtration rate; OMT: Optimal medical therapy = guideline-directed medical therapy; SIHD: Stable ischemic heart disease.