Peroxisome proliferator-activated receptors for hypertension

Figure 1 Schematic structure of peroxisome proliferator-activated receptor protein isoforms. A/B, C, D, and E/F indicate the N-terminal A/B domain containing a ligand-independent AF-1, the DBD, the hinge region, and the C-terminal LBD containing AF-2, respectively. AF-1 is responsible for phosphorylation, while AF-2 promotes the recruitment of co-activators for gene transcription. PPAR: Peroxisome proliferator-activated receptor; AF-1: Activation function-1; DBD: DNA-binding domain; HD: Hinge domain; LBD: Ligand-binding domain. Figure adapted from reference[8].