High-density lipoprotein and atherosclerosis: Roles of lipid transporters

Figure 4 In vitro promoter activity assay for ATP-binding G1 promoter-A. ATP-binding cassette transporter G1 (ABCG1) promoter construct with a −257T/G mutation, −394 T/G from the transcription start site (NM_207627.1: c.-394T > G) on ABCG1 promoter-A, which is reported to be a functional promoter with an LXR-responsive element. A: ABCG1 transcription activity on a construct that contains the T or G allelic sequence; B: ABCG1 transcription activity induced by 5 μmol/L of T0901317 (T0) and 9-cis-retinoic acid (9cisRA) on constructs that contain the T or G allelic sequence. Results are expressed as mean ± SD. Graphs are modified from the paper by Furuyama et al[67]. ABC: ATP-binding cassette; RXR: Retinoid X receptor; LXR: Liver X receptor.