High-density lipoprotein and atherosclerosis: Roles of lipid transporters

Figure 3 Response of liver X receptor and retinoid X receptor agonists to human ATP-binding G1 promoter activities in RAW264 cells. A: Human wild-type ATP-binding cassette transporter G1 (ABCG1) promoter-A located upstream of exon 1; B: Human wild-type ABCG1 promoter-B located upstream of exon 5; C: ABCG1 promoter (promoter-A; upstream of exon 1) vectors that contain a truncated 5′-region of the ABCG1 gene. After transfection, cells were incubated with or without agonists of LXR [22(R)-hydroxycholesterol, 10 μmol/L] and RXR (9-cis-retinoic acid, 10 μmol/L). Results are expressed as mean ± SD. Graphs modified from the paper by Uehara et al[62]. LXR: Liver X receptor; RXR: Retinoid X receptor; RLU: Relative luciferase units .