Challenges in the chemotherapy of Chagas disease: Looking for possibilities related to the differences and similarities between the parasite and host

Figure 5 Structures of cruzain and its ligands. A: Three-dimensional structural representation of cruzain crystallized with vinyl sulfone derivative (3). Structure deposited in the Protein Data Bank under the code 1F2C[45]; B: Schematic representation in two dimensions of the binding mode of (3) to cruzain generated by LigPlot⁺ software upon the PDB file; C: Structures of the cruzain inhibitor derivatives (3) and (4).