Connective tissue growth factor differentially binds to members of the cystine knot superfamily and potentiates platelet-derived growth factor-B signaling in rabbit corneal fibroblast cells

Figure 4 Connective tissue growth factor enhances platelet-derived growth factor-BB binding to platelet-derived growth factor receptor β in surface plasma resonance analysis. PDGF-BB (2 nmol/L) was mixed with different concentrations of CTGF (0-263.2 nmol/L) and run over PDGFRβ sensor chips. SPR response units were measured and used for quantitative comparisons of interaction between PDGF-BB and PDGFRβ in presence of different concentrations of CTGF proteins in Figure 3B. Representative sensorgrams from two independent trials are shown. CTGF: Connective tissue growth factor; PDGF-B: Platelet-derived growth factor-B; PDGFRβ: Platelet-derived growth factor receptor β.