Regulation of MYC gene expression by aberrant Wnt/β-catenin signaling in colorectal cancer

Figure 2 The MYC genomic locus in colorectal cancer. ChIP-Seq and DHS data in the HCT116 CRC cell line were downloaded from the WashU Epigenome Browser (http://epigenomegateway.wustl.edu/). The MYC distal super-enhancer is denoted as a purple rectangle, the MYC WREs discussed in this review are depicted as red lines, and potential WREs are denoted as blue lines[50,73]. WRE: Wnt responsive DNA element; CTCF: CCCTC-binding factor; H3K4me1: Monomethylated lysine 4 on histone H3; H3K27Ac: Acetylated lysine 27 on histone H3; RNAP: RNA Polymerase II; TCF: T-cell factor; CCAT: Colon-cancer associated transcript; DHS: DNase hypersensitivity.