“Stop Ne(c)king around”: How interactomics contributes to functionally characterize Nek family kinases

Figure 2 Global interactome of Nek1-11, involving their published interactors. The proteins color code refers to their main biological function given by the top enriched Gene Ontology[125] biological processes (P≤ 0.05). Common interactors establish crosslinks between Neks, thereby emphasizing their common functional contexts. The protein sizes are depicted proportional to their connectivity degree. The protein-protein interaction network was built for the first neighbors of Neks using the Integrated Interactome System (IIS) platform, developed at National Laboratory of Biosciences, Brazil (http://www.lge.ibi.unicamp.br/lnbio/IIS/) and visualized using the Cytoscape software[¹²⁶]. Nek: Never in mitosis-gene A-related kinases.