Yeast nuclear RNA processing

Figure 5 Rrp6p. A: Crystal structure of Saccharomyces cerevisiae Rrp6p. The NTD is colored yellow, the exonuclease domain is colored green, and the HRDC domain is colored purple (RCSBID: 2HBJ); B: Schematic representation of the two different ways that Rrp6p functions in RNA degradation and processing. Scheme 1: Rrp6p interacts with the nuclear exosome to facilitate processing or degradation; Scheme 2: Rrp6p interacts with Rrp47 allowing Rrp6p to bind to RNA with secondary structure[145].