p53 in stem cells

Figure 3 Antagonistic regulation of differentiation of neural stem cells by Arf/p53 and Myc. Myc regulates self-renewal of neural stem cells (NSCs) and enhances their differentiation into the neuronal lineage. At early stages of embryogenesis, myc expression is high and p19^Arf expression is low. Later in development, mitogenic signals upregulate p19^Arf expression, resulting in enhanced abundance of the p53 tumor suppressor protein, which suppresses self-renewal of NSCs and differentiation towards the neuronal lineage while it supports gliogenesis [100].