Up a lymphoid blind alley: Does CALM/AF10 disturb Ikaros during leukemogenesis?

Figure 1 Model of the CALM/AF10 Ikaros interaction during leukemogenesis (adapted from Greif et al[5], 2008). Hematopoietic stem cells (HSC) give rise to multipotent progenitors (MPP) that divide into common lymphoid (CLP) and myeloid progenitors (CMP). Ikaros is required for the maturation of lymphoid progenitors. We propose that CALM/AF10 alters its subcellular localization[5] and thereby disturbs Ikaros function at this stage leading to impaired thymocyte differentiation[15] and phenotypically acute myeloid leukemia (AML) with lymphoid characteristics[8]