Recent perspectives into biochemistry of decavanadate

Figure 6 Scheme of proposed decavanadate (V₁₀) cellular targets. V₁₀ uptake through anionic channels (AC). Decavanadate might interact with membrane proteins. V₁₀ formation upon intracellular vanadium acidification in cytosol, but most probably in acidic organelles. Reduction of monomeric vanadate (V₁) by antioxidant agents. Binding of V₁₀ to target proteins; it is proposed that V₁₀ accumulates in subcellular organelles, such as mitochondria, affecting its function. Decavanadate also targets the contractile system, and its regulation, as well as calcium homeostasis (adapted from[14]).