Benfang Lei’s research on heme acquisition in Gram-positive pathogens and bacterial pathogenesis

Figure 2 Cartoons for the proposed pathway of heme acquisition from metHb by the Staphylococcus aureus Isd (A) and Group A Streptococcus Shr/Shp/HtsABC (B) systems. The arrows indicate the direction of direct heme transfer. Heme transfer from IsdB to IsdC represented by the dotted arrow may be prevented in vivo by their physical locations in the cell wall. The structure models of the proteins were from the coordinates 2Q8Q, 2ITF, 2O6P, 2Q7A, and 1HHO. This figure was originally published in J Biol Chem. Zhu H, Xie G, Liu M, Olson JS, Fabian M, Dooley DM, Lei B. Pathway for heme uptake from human methemoglobin by the iron-regulated surface determinants system of Staphylococcus aureus. J Biol Chem 2008; 283: 18450-18460[23].