Contribution of plasma membrane Ca2+ ATPase to cerebellar synapse function

Figure 3 Intact CF evoked excitatory post-synaptic currents in PMCA2^-/- PNs. A: Representative traces of CF-evoked excitatory post-synaptic currents, EPSCs (stimulation shown by downward arrows) from individual mouse PNs voltage clamped at -20 mV. Patch electrodes contained 5mM QX314 to prevent the occurrence of Na⁺ dependent action potentials. Note that the second response, EPSC was smaller than the first, indicating a relative depression of the second EPSC (paired pulse depression) consistent with the high release probability of glutamate at the CF synapse[21]; B: There was no significant difference in the amplitude of the first EPSC; C: No significant difference in the extent of paired pulse depression. Values are mean ± SE error bars.