Glucagon receptor gene mutations with hyperglucagonemia but without the glucagonoma syndrome

Figure 3 Membrane topology prediction. The loss of 11 amino acids from the glucagon receptor (GCGR) 6^th transmembrane domain is predicted to prevent the insertion of GCGR into the plasma membrane. A: Predicted normal GCGR membrane topology; B: Predicted K349_G359del GCGR membrane topology. Software used: Meta^TM[22]; input amino acid sequence shown in Figure 2B. DAS: Distributed Annotation System.