Published online Nov 27, 2023. doi: 10.4240/wjgs.v15.i11.2490
Peer-review started: August 13, 2023
First decision: September 20, 2023
Revised: October 3, 2023
Accepted: October 23, 2023
Article in press: October 23, 2023
Published online: November 27, 2023
The hepatic venous pressure gradient (HVPG), rather than the portal venous pressure gradient (PPG), is regarded as the gold standard for diagnosing portal hypertension (PHT).
The relationship between HVPG and PPG is controversial and lacks substantial research to prove it.
This study aimed to classify the correlation between HVPG and PPG in patients with alcoholic cirrhosis and PHT.
This retrospective analysis of various pressures during transjugular intrahepatic portosystemic shunt (TIPS) procedures explored the relationship between HVPG and PPG in patients with alcoholic cirrhosis and PHT.
The correlation coefficient (r) and determination coefficient (R2) between HVPG and PPG were 0.201 and 0.040, respectively (P = 0.020). Hepatic collaterals were identified in 26 patients with balloon occlusion hepatic venography (19.4%), while the average PPG was significantly higher than the average HVPG (25.94 ± 7.42 mmHg vs 9.86 ± 7.44 mmHg; P < 0.001). The collateral versus no collateral branches groups had 3 (11.54%) and 44 (40.74%) patients, respectively, with differences of < 5 mmHg between HVPG and PPG.
HVPG cannot accurately represent PPG in most patients. The formation of hepatic collaterals is a vital reason for the strong underestimation of HVPG.
Based on different pressures during TIPS procedures, the correlation and differences between HVPG and PPG of patients were explored.