Published online Mar 27, 2023. doi: 10.4240/wjgs.v15.i3.488
Peer-review started: November 26, 2022
First decision: January 3, 2023
Revised: January 15, 2023
Accepted: February 16, 2023
Article in press: February 16, 2023
Published online: March 27, 2023
Xanthogranulomatous inflammation (XGI) is an uncommon process involving an accumulation of inflammatory cells, commonly lipid-laden macrophages. XGI has been described to occur throughout the body but only rarely in the lower gastrointestinal tract. We describe a case of XGI contributing to chronic ob
We report the case of a 42-year-old female who presented with intermittent epigastric pain and subjective fevers. She had undergone a laparoscopic small bowel resection for Meckel’s diverticulum five years prior. Her workup was notable for computed tomography scan demonstrating mild inflammation and surrounding stranding at the level of the prior anastomosis. She underwent a laparotomy, resection of the prior anastomosis and re-anastomosis, with final histopathological examination findings consistent with mural XGI.
XGI can occur at the site of a prior bowel anastomosis and cause chronic obstructive symptoms.
Core Tip: Xanthogranulomatous inflammation (XGI) is an uncommon inflammatory condition characterized by foamy histiocytes and other inflammatory cells. We report a rare case of XGI that occurred in the terminal ileum. Moreover, this is the first reported case of XGI associated with a prior bowel anastomosis. This case enhances our understanding of XGI and provides more insight into the pathophysiology of the condition.