Published online Nov 27, 2023. doi: 10.4240/wjgs.v15.i11.2463
Peer-review started: July 27, 2023
First decision: August 10, 2023
Revised: August 18, 2023
Accepted: October 17, 2023
Article in press: October 17, 2023
Published online: November 27, 2023
Clinical prognosis often worsens due to high recurrence rates following radical surgery for colon cancer. The examination of high-risk recurrence factors post-surgery provides critical insights for disease evaluation and treatment planning.
To explore the relationship between metastasis-associated factor-1 in colon cancer (MACC1) and vacuolar ATP synthase (V-ATPase) expression in colon cancer tissues, and recurrence rate in patients undergoing radical colon cancer surgery.
We selected 104 patients treated with radical colon cancer surgery at our hospital from January 2018 to June 2021. Immunohistochemical staining was utilized to assess the expression levels of MACC1 and V-ATPase in these patients.
The rates of MACC1 and V-ATPase positivity were 64.42% and 67.31%, respe
The upregulated expression of MACC1 and V-ATPase in colon cancer patients appears to correlate with clinicopathological features and post-radical surgery recurrence.
Core Tip: The abnormal expression of colon cancer metastasis-related factor-1 and vacuolar ATP synthase in colon cancer tissues is related to the clinicopathological characteristics of patients, and is related to the recurrence of colon cancer after radical resection.