Review
Copyright ©The Author(s) 2016.
World J Diabetes. Dec 15, 2016; 7(20): 572-598
Published online Dec 15, 2016. doi: 10.4239/wjd.v7.i20.572
Figure 15
Figure 15 Theoretic model to assess glucose tolerance as a factor of weight. Liraglutide 3 mg produces increased weight loss and increased improvements in glucose control compared to both placebo and control in non-diabetic obese and overweight subjects[41-43,205,206]. If the greater glucose sensitivity seen following treatment with liraglutide 3 mg is secondary to the greater weight loss achieved, the relationship between a given weight reduction and the percentage improvement in glucose tolerance should be the same in all treatment groups (A). If however, the relationship between a given weight loss and change in glucose tolerance is less strong (B) following treatment with liraglutide, findings would suggest that mechanisms beyond weight loss contribute to the greater improvements of glucose tolerance seen following GLP-1 agonism. One mechanism may be via activation of GLP-1R in the pancreas, where endogenous GLP-1 signalling has a well established incretin effect. GLP-1: Glucagon-like peptide 1.