Glucagon-like peptide 1 in the pathophysiology and pharmacotherapy of clinical obesity

Figure 8 Effects of obesity on glucagon-like peptide 1 responses post oral glucose load and post-prandial. Obese subjects consistently demonstrate reduced glucagon-like peptide 1 (GLP-1) secretory responses following a 75-g oral glucose load compared to lean controls. Post-prandial GLP-1 secretory responses in obese subjects are conflicting, with some studies observing significant reductions and others observing no change[168-178] when compared to lean controls.