Update on the treatment of type 2 diabetes mellitus

Figure 3 Therapeutic algorithm in patients with type 2 diabetes mellitus and chronic kidney disease. Adapted from Gómez-Huelgas et al[338]. ^aAvoid Glibenclamide. Use Gliclazide, Glipizide and Gliquidone. Use Glimepiride only if eGFR > 60 mL/min; ^bDose adjustment, except linagliptin; ^cMonitor fluid retention; ^dAdjust doses of exenatide and lixisenatide; ^eGenerally not use Metformin. Use only half the dose and monitor renal function; ^fNot recommended if eGFR < 60 mL/min. eGFR: Estimated glomerular filtration rate; HbA1c: Glycated haemoglobin; GLP-1: Glucagon-like peptide-1; SGLT2: Sodium-glucose co-transporter 2; DPP-4: Dypeptydil peptidase-4.