How the kidney hyperfiltrates in diabetes: From molecules to hemodynamics

Figure 3 Expression of cennexins (Cx37, 40, 43) in juxtaglomerular apparatus of type 2 diabetic (Zucker diabetic fatty) and control (Zucker lean) rats. A, B, D, E: Renin secreting cells (RSC, blue) and endothelial cells (EC) express Cx37 (A: Lean; D: Fat) and Cx40 (B: Lean; E: Fat). Cx40 is expressed on glomerular and extraglomerular mesangial cells (EGM) in control (B) and diabetes (E). Cx43 is expressed in cytosol of RSC in both groups (C, F). Quantification reveals that the expression of Cx37 in RSC is reduced in diabetic model[15].