Transcriptional factors, Mafs and their biological roles

Figure 1 Immunostaining for MAFA, MAFB, and c-MAF in fetal and adult human pancreas tissues. An immunohistochemical analysis was performed using primary antibodies against MAFA (BL1069; Bethyl Laboratories, Inc.), MAFB (P20; Santa Cruz Biotechnology, Inc.), and c-MAF (M153; Santa Cruz Biotechnology, Inc.). The details are described in reference[28]. Samples of human normal fetal tissue (female, 20 wk, catalog No. T2244188, Lot No. A607380) and adult pancreas tissue (male, 23 years, catalog No. T2234188, Lot No. A604382) were purchased from BioChain. The fetal pancreas tissues were diffusely stained for the Maf transcription factors, and characteristic histological differences were observed between the fetal and adult tissues, with a more intense staining pattern observed in the islet areas of the adult pancreas tissue.