Alteration of mitochondrial function in adult rat offspring of malnourished dams

Figure 2 Summary of the main consequences of prenatal malnutrition on metabolic pathways in islets from low protein diet, global food restriction and high fat diet. As shown in the text and extensively described in the related publications[53,63], the entrance of glucose was analyzed through GLUT-2 expression, the glycolysis through glucokinase expression, the TCA through citrate synthase and malate dehydrogenase expression. Reactive oxygen species production, ATP content and insulin secretion in response to glucose were also determined. The arrows indicated an increased or decreased level compared to control offspring. A: Males; B: Females; GLUT: Glucose transporter; TCA: Tricarboxylic acid cycle; GFR: Global food restriction; LP: Low protein diet; HF: High fat diet; ROS: Reactive oxygen; UCP: Uncoupling proteins species.