A defect in the activities of Δ6 and Δ5 desaturases and pro-resolution bioactive lipids in the pathobiology of non-alcoholic fatty liver disease

Figure 6 Scheme showing the role of eicosanoids, lipoxins, resolvins, protectins and maresins in resolution of non-alcoholic fatty liver disease. Green arrows indicate events that will lead to resolution of non-alcoholic fatty liver disease (NAFLD). Red arrows indicate events that will lead to initiation and/or progression of NAFLD. (-): Inhibition or suppression of action; (+): Activation or enhancement of action; TNF-α: Tumor necrosis factor-α; LXs: Lipoxins; COX: Cyclo-oxygenase; LO: Lipoxygenase; PG: Pro-inflammatory prostaglandin. For further details see[82-90,119].