A defect in the activities of Δ6 and Δ5 desaturases and pro-resolution bioactive lipids in the pathobiology of non-alcoholic fatty liver disease

Figure 5 Scheme showing the synthesis of neuroprotectin D1. Resolvins are generated in brain tissue in response to aspirin treatment and in addition, docosatrienes termed neuroprotectins are also produced. The lipoxygenase product 17S-hydroperoxy-DHA is converted first to a 16(17)-epoxide and then to the 10, 17-dihydroxy docosatriene denoted as 10, 17 S-DT or NPD1. As with the leukotrienes, there are three double bonds in conjugation, hence the term “triene”, although there are six double bonds in total. Figures 2-5 are from[27,31,32,64,119]. DHA: Docosahexaenoic acid.