Review
Copyright ©The Author(s) 2019.
World J Diabetes. Oct 15, 2019; 10(10): 490-510
Published online Oct 15, 2019. doi: 10.4239/wjd.v10.i10.490
Figure 3
Figure 3 Randle cycle. The glucose-fatty acid (Randle) cycle in muscle. Oxidation of fatty acids inhibits pyruvate dehydrogenase. Citrate inhibits phosphofructokinase. The rise in glucose-6-phosphate inhibits hexokinase[153]. FFA: Fatty acids; HK: Hexokinase; PDH: Pyruvate dehydrogenase; PFK: Phosphofructokinase; UDP: Uridine diphosphate; GLUT 4: Glucose transporter 4; OOA: Oxaloacetic acid.