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World J Diabetes. Dec 15, 2014; 5(6): 756-762
Published online Dec 15, 2014. doi: 10.4239/wjd.v5.i6.756
Published online Dec 15, 2014. doi: 10.4239/wjd.v5.i6.756
Recent advances on the association of apoptosis in chronic non healing diabetic wound
Awadhesh K Arya, Faculty of Health Sciences, Department of Microbiology, Immunology and Genetics, Ben Gurion University of The Negev, Beer Sheva 8410501, Israel
Richik Tripathi, Department of Maxillofacial Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India
Santosh Kumar, Kamlakar Tripathi, Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India
Author contributions: Arya AK and Tripathi K had designed the outlook and written most part of the manuscript; Tripathi R and Kumar S helped in editing and collection of articles to be incorporated in the manuscript.
Correspondence to: Kamlakar Tripathi, Professor, Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, Varanasi 221005, India. kamlakar_tripathi@yahoo.co.in
Telephone: +91-542-6703324 Fax: +91-542-2307521
Received: August 21, 2014
Revised: October 28, 2014
Accepted: November 7, 2014
Published online: December 15, 2014
Revised: October 28, 2014
Accepted: November 7, 2014
Published online: December 15, 2014
Core Tip
Core tip: Uncontrolled diabetes mellitus lead to the chronic non healing wound which further can escort to the Ischemia and coronary artery disease. Reports suggested that the involvement of various mechanisms in the development of chronic non healing wound in patients with diabetes mellitus, among which the oxidative stress plays a pivotal role which then leading to the enhanced apoptosis of lymphocytes, may be playing a critical role in the delay of wound healing. Connexins are gap junction protein and their upregulation during diabetes might be leads to improper gap junction formation attributing to the passage of various, apoptotic and inflammatory signals thereby resulting in delayed healing of chronic diabetic ulcers.