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World J Diabetes. Dec 15, 2013; 4(6): 339-348
Published online Dec 15, 2013. doi: 10.4239/wjd.v4.i6.339
Published online Dec 15, 2013. doi: 10.4239/wjd.v4.i6.339
Changes of phasic and tonic smooth muscle function of jejunum in type 2 diabetic Goto-Kakizaki rats
Jing-Bo Zhao, Department of Gastroenterology and Surgery, Aalborg University Hospital, DK 9000 Aalborg, Denmark
Peng-Min Chen, Department of Molecular Biology, Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing 100029, China
Jing-Bo Zhao, Hans Gregersen, The College of Bioengineering, Chongqing University, Chongqing 400044, China
Hans Gregersen, The GIOME Institute, GIOME FZE, Ras Al-Khaimah 6300, United Arab Emirates
Author contributions: Zhao JB and Chen PM designed the research, performed the experiment, analyzed the data and wrote the manuscript; Gregersen H participated in the study design and revised the manuscript and English grammar.
Supported by Karen Elise Jensens Foundation
Correspondence to: Jing-Bo Zhao, Associate Professor, Mech-Sense, Department of Gastroenterology and Surgery, Aalborg University Hospital, Sdr. Skovvej 15, DK9000 Aalborg, Denmark. jz@rn.dk
Telephone: +45-993-26907 Fax: +45-993-26801
Received: May 1, 2013
Revised: September 15, 2013
Accepted: October 17, 2013
Published online: December 15, 2013
Revised: September 15, 2013
Accepted: October 17, 2013
Published online: December 15, 2013
Core Tip
Core tip: Length-tension diagrams of smooth muscle strips were obtained in intact segment of intestine in vitro in the present study. We demonstrated that it is a valid tool to evaluate smooth muscle function in intact intestine. Diabetes decreased the force (stress) generated by the smooth muscle normalized to the muscle layer thickness. Since the stress decreased and the muscle layer thickness increased in diabetic rats, it indicates that the intestine, at least in part, remodels in a stress-dependent way. Furthermore, the smooth muscle in Goto-Kakizaki diabetic intestine preserved its response to carbachol stimulation.