Rojas A, González I, Morales E, Pérez-Castro R, Romero J, Figueroa H. Diabetes and cancer: Looking at the multiligand/RAGE axis. World J Diabetes 2011; 2(7): 108-113 [PMID: 21860695 DOI: 10.4239/wjd.v2.i7.108]
Corresponding Author of This Article
Armando Rojas, PhD, Associate Professor and Head, Biomedical Research Labs., Medicine Faculty, Catholic University of Maule, Talca, POB 617, Chile. arojasr@ucm.cl
Article-Type of This Article
Guidelines For Basic Research
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Armando Rojas, Ileana González, Erik Morales, Ramón Pérez-Castro, Jacqueline Romero, Héctor Figueroa, Biomedical Research Labs., Medicine Faculty, Catholic University of Maule, Talca, POB 617, Chile
Author contributions: Rojas A contributed to the original idea, literature search, manuscript writing and final revision of the article; Gonzalez I, Morales E, Pérez-Castro R, Romero J and Figueroa H contributed to literature search, the manuscript writing and the final revision of the article. All authors approved the final manuscript
Supported by the Fondecyt Grant 1090340
Correspondence to: Armando Rojas, PhD, Associate Professor and Head, Biomedical Research Labs., Medicine Faculty, Catholic University of Maule, Talca, POB 617, Chile. arojasr@ucm.cl
Telephone: +56-71-203134 Fax: +56-71-413657
Received: May 5, 2011 Revised: June 21, 2011 Accepted: June 28, 2011 Published online: July 15, 2011
Abstract
The association between diabetes and hyperglycemia and the associated increased risk of several solid and hematologic malignancies has been the subject of investigation for many years. Although the association is not fully understood, current knowledge clearly indicates that diabetes may influence malignant cell transformation by several mechanisms, including hyperinsulinemia, hyperglycemia and chronic inflammation. In this context, the receptor for advanced glycation end-products (RAGE) has emerged as a focal point in its contribution to malignant transformation and tumor growth. We highlight how RAGE, once activated, as it manifests itself in conditions such as diabetes or hyperglycemia, is able to continuously bring about an inflammatory milieu, thus supporting the contribution of chronic inflammation to the development of malignancies.