Published online Oct 15, 2020. doi: 10.4239/wjd.v11.i10.425
Peer-review started: June 25, 2020
First decision: July 30, 2020
Revised: August 11, 2020
Accepted: August 31, 2020
Article in press: August 31, 2020
Published online: October 15, 2020
Processing time: 111 Days and 0.5 Hours
Diabetes is a progressive disease that increases glucose levels in the blood. While studies have shown that patients with pulmonary disease (both obstructive and restrictive pulmonary disease) have a higher prevalence of type 2 diabetes mellitus (T2DM), there have been more studies on restrictive patterns than chronic obstructive pulmonary disease.
To assess whether restrictive and obstructive pulmonary diseases are associated with T2DM in Koreans.
For our analysis, we used data from the Korea National Health and Nutrition Examination Survey. A total of 2830 subjects were included in this study. Spirometry results were categorized into three patterns: Normal, restrictive pulmonary disease (RPD), and obstructive pulmonary disease (OPD).
The factors used as diabetic indicators (i.e. homeostatic model assessment of insulin resistance, homeostatic model assessment of beta-cell function, glycated hemoglobin, and fasting insulin) were among the highest in RPD but not in OPD. Based on multivariate logistic regression analysis, subjects with RPD were found with an increased odds ratio [OR: 1.907, 95% confidence interval (CI): 1.110-3.277] for T2DM compared with subjects with normal pulmonary function, whereas in patients with OPD, the OR had not increased. Model 4, which adjusted for the variables that could affect diabetes and pulmonary disease, showed a significant increase in the T2DM OR to RPD (OR: 2.025, 95%CI: 1.264-3.244). On the other hand, no statistically significant difference was shown in OPD (OR: 0.982, 95%CI: 0.634-1.519).
RPD, not OPD, is highly associated with T2DM regardless of the risk factors of various T2DMs that can be confounds.
Core Tip: This study was performed to assess whether restrictive and obstructive patterns of pulmonary disease and type 2 diabetes mellitus (T2DM) are associated with each other in Koreans. For our analysis, we used data from the Korea National Health and Nutrition Examination Survey. A total of 2830 subjects were included in this study. Spirometry results were categorized into three patterns: normal, restrictive, and obstructive pulmonary disease. Restrictive pulmonary disease, not obstructive disease, is highly relevant to T2DM regardless of other risk factors of various T2DMs that can be confounds.