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©The Author(s) 2020.
World J Gastrointest Oncol. Sep 15, 2020; 12(9): 942-956
Published online Sep 15, 2020. doi: 10.4251/wjgo.v12.i9.942
Published online Sep 15, 2020. doi: 10.4251/wjgo.v12.i9.942
Figure 2 Thymidylate synthase inhibition.
Fluorodeoxyuridine monophosphate (FdUMP) incorporation into thymidylate synthase in place of deoxyuridine monophosphate (dUMP) results in suppression of thymidylate synthase (TS). Consequently, the synthesis of thymidine monophosphate required for DNA replication and repair is diminished, which leads to deoxyuridine triphosphate (dUTP) imbalances, increased dUTP, DNA damage and finally apoptosis of actively dividing cancerous cells[20]. TK: Thymidylate kinase; CH2THF: 5,10-methylene tetrahydrofolate; dTMP: Deoxythymidine monophosphate; dTTP: Deoxythymidine triphosphate; dNTP: Deoxynucleotide triphosphate.
- Citation: Sabeti Aghabozorgi A, Moradi Sarabi M, Jafarzadeh-Esfehani R, Koochakkhani S, Hassanzadeh M, Kavousipour S, Eftekhar E. Molecular determinants of response to 5-fluorouracil-based chemotherapy in colorectal cancer: The undisputable role of micro-ribonucleic acids. World J Gastrointest Oncol 2020; 12(9): 942-956
- URL: https://www.wjgnet.com/1948-5204/full/v12/i9/942.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v12.i9.942