Recent advances in targeted endoscopic imaging: Early detection of gastrointestinal neoplasms

Figure 1 Images from wide-field endoscopy videos after topical application of fluorescence-labeled peptides. The left and right columns represent frames from white light and fluorescence endoscopy, respectively. A: Multiple adenomas; B: Single adenoma in a CPC; Apc mouse. The fluorescently labeled target peptide shows positive binding to multiple adenomas and a single adenoma; C: The control peptide shows minimal binding to a single adenoma; D:Control mouse lacking Cre recombinase transgene; E:The hyperplastic epithelium in a mutant K-ras mouse model. The target peptide also shows minimal binding to control mouse and hyperplastic epithelium. White arrows identify adenomas. Reproduced from Miller et al[30].