Published online Apr 16, 2023. doi: 10.4253/wjge.v15.i4.248
Peer-review started: December 12, 2022
First decision: February 1, 2023
Revised: February 9, 2023
Accepted: March 30, 2023
Article in press: March 30, 2023
Published online: April 16, 2023
Due to the high risk of morbidity and mortality associated with surgical resection in this tract, endoscopic resection (ER) has taken the place of surgical resection as the first line treatment for non-ampullary duodenal adenomas. However, due to the anatomical characteristics of this area, which enhance the risk of post-ER problems, ER in the duodenum is particularly difficult. Due to a lack of data, no ER technique for superficial non-ampullary duodenal epithelial tumours (SNADETs) has yet been backed by strong, high-quality evidence; yet, traditional hot snare-based techniques are still regarded as the standard treatment. Despite having a favourable efficiency profile, adverse events during duodenal hot snare polypectomy (HSP) and hot endoscopic mucosal resection, such as delayed bleeding and perforation, have been reported to be frequent. These events are primarily caused by electrocautery-induced damage. Thus, ER techniques with a better safety profile are needed to overcome these shortcomings. Cold snare polypectomy, which has already been shown as a safer, equally effective pro
Core Tip: A high risk of adverse events has been associated with endoscopic resection of non-ampullary duodenal adenomas. As cold snare polypectomy demonstrated a better safety profile and a similar efficacy comparing with conventional hot polypectomy in the colon, it has been increasingly considered also in the duodenum over the very last few years. Goal of this review is to summarize efficiency and safety outcomes of cold resection as a treatment for non-ampullary duodenal adenomas.