Meta-analysis reveals up-regulation of cholesterol processes in non-alcoholic and down-regulation in alcoholic fatty liver disease

Figure 5 The pluripotent stem cell models of alcoholic liver disease and non-alcoholic fatty liver disease reflect the characteristics of the biopsy-derived gene signature. The gene signature condensed from the meta-analysis of multiple ALD and NAFLD gene expression datasets was applied to the steatosis-model by (Graffmann et al[40]) where pluripotent-stem-cell-derived hepatocyte-like cells (HLCs) were challenged with ethanol (E) and oleic acid (OA). The cluster analysis shows a clear separation into the ethanol model (red bar) and the oleic acid model (blue bar). ALD: Alcoholic liver disease; NAFLD: Non-alcoholic fatty liver disease.